9/26/2023 0 Comments Instal Pipette 23.6.13We propose that decreases in aversive AGRP neuron activity 6 mediated by this food-specific circuit increases the incentive salience 13 of food cues, and thus facilitates the learning of food-acquisition tasks. This is specific for food, as learning of an identical water-acquisition task is unaffected. Interference with this circuit impairs food cue inhibition of AGRP neurons and, notably, greatly impairs learning of a sensory cue-initiated food-acquisition task. Here, we show that a lateral hypothalamic glutamatergic → dorsomedial hypothalamic GABAergic (γ-aminobutyric acid-producing) 12 → AGRP neuron circuit mediates this regulation. To evaluate this, we first identified the circuit mediating sensory cue inhibition and then selectively perturbed it to determine function. Given that AGRP neuron activity is aversive 6, the sensory cue-linked reductions in activity could function to guide behaviour. The rapid regulation by food cues is of particular interest as its neurobiological basis and purpose are unknown. Eating returns AGRP neuron activity towards baseline on three distinct timescales: rapidly and transiently following sensory detection of food cues 6, 7, 8, slowly and longer-lasting in response to nutrients in the gut 9, 10, and even more slowly and permanently with restoration of energy balance 9, 11. Agouti-related peptide (AGRP)-expressing neurons are activated by fasting-this causes hunger 1, 2, 3, 4, an aversive state that motivates the seeking and consumption of food 5, 6.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |